![]() ![]() ![]() ![]() Exercise training and resveratrol supplementation, or both, improved overall aortic morphology with no change in pulse wave velocity.Īlzheimer’s disease (AD) is the most common form of dementia in the United States. Aortic wall and adventitia thickness were increased in 3xTg mice compared to the WT group. Pulse wave velocity was ~33% higher in 3xTg, and accompanied by a significant increase in elastin fiber fragmentation within the aortic wall, which was associated with decrease in elastin content and fiber length. Treadmill exercise training and resveratrol supplementation in the diet for 5 months improved ejection fraction, fractional shortening, and restored diastolic deceleration times. Late (A) ventricular filling velocities, the early/atrial (E/A) ratio, and mitral valve deceleration time, all indices of diastolic function, were increased in 3xTg mice compared to WT mice. Systolic function, expressed as ejection fraction and fractional shortening, were decreased in 3xTg mice. Our findings indicated that aortic root measurements and interventricular septal dimensions were similar in 3xTg and wild-type mice. ![]()
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May 2023
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